Microarray Core Facility

Quan-Zhen Li, Ph.D, MD

Associate Professor
Department of Immunology and Internal Medicine
Director of Microarray Core Facility
University of Texas Southwestern Medical Center
6001 Forest Park Rd./ND6.504
Dallas, Texas 75390-8814

Office Location: 6001 Forest Park Rd./ND6.502
Phone: 214-645-6073
Email: quan.li@utsouthwestern.edu

Sun-Yet Sun University of Medical Science, China
M.D., Ph.D. Pathogenic Biology


University of Florida Medical School, Pathology
University of Texas Southwestern Medical Center, Immunology

Research Interest:

Developing and using high through-put microarray, 2nd-generation sequencing and other genomic analysis tools to identify and characterize disease-related genes and pathways.

Recent Publications:
  1. Xu A, et al. TGF-β-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. J Immunol. 2016 Mar 21
  2. Pathak S et al. Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in LupusJ Immunol. 2016 Feb 15;196(4)
  3. Kramer J, et al. Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome.J Leukoc Biol. 2016 Feb;99(2):321-31.
  4. Hasan M, et al. Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice J Immunol. 2015 Nov 15
  5. Wei JH, et al. A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma.Nat Commun. 2015 Oct 30;6:8699.
  6. Gao D, et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.Proc Natl Acad Sci U S A. 2015 Oct 20
  7. Hasan M, et al. Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.Immunity. 2015 Sep 15;43(3):463-74.
  8. Mayeux J, et al. Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.J Immunol. 2015 Sep 1;195(5):1955-63.
  9. Huang QQ , et al. CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis. Nat Commun. 2015 May 12:6:7086
  10. Shao X, et al. Inducible expression of kallikrein in renal tubular cells protect mice from spontaneous lupus nephritis.Arthritis Rheum. 2013; 65(3): 780-791 PMID: 23280471
  11. Gutierrez T, et al. IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.Eur. J. Immunol. 2012. 43: 1–12 PMID: 23169140
  12. Chong BF, et al. IgG and IgM Autoantibody Differences in Discoid and Systemic Lupus Patients. J Invest Dermatol. 2012;132(12):2770-9. PMID: 22763789
  13. Xia Y, et al. The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies. Journal of Autoimmunity 2012; 39: 398-411 PMID: 22841793
  14. Li Y, Wang H, et al. Influence of Carbon Monoxide on Growth and Apoptosis of Human Umbilical Artery Smooth Muscle Cells and Vein Endothelial Cells. Int J Biol Sci. 2012; 8(10): 1431-46
  15. Olsen NJ, et al. Autoantibody profiling to follow evolution of lupus syndromes. Arthritis Res Ther. 2012; 14(4): R174.
  16. Wu T, et al. Metabolic disturbances associated with systemic lupus erythematosus. PLoS One. 2012; 7(6):e37210.
  17. Li L, et al. Murine lupus strains differentially model unique facets of human lupus serology. Clin Exp Immunol. 2012;168(2):178-85. doi: 10.1111/j.1365-2249.2012.04568.x
  18. Tan BK, et al. Evidence for intranasal anti-nuclear antibodies in Chronic Rhinosinusitis with Nasal Polyps. J Allergy Clin Immunol; 2011; 128(6):1198-1206.e1 PMID: 21996343
  19. O'Neill SK, et al. Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy. Immunity; 2011; 35(5):746-56 PMID: 22078222
  20. Stoll ML, et. Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. Clin Exp Rheumatol. 2011 Jul-Aug;29(4):736-42.
  21. Li QZ, et al. Risk factors for ANA positivity in healthy persons. Arthritis Res Ther. 2011 Mar 2
  22. Li QZ,et al. Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes.Clin Exp Immunol. 2010 Mar;159(3):281-91. Epub 2009 Dec 1.
  23. Li QZ, et al. The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulongphritis. Genes & Immun, March 5 2009. doi:10.1038/gene.2009.7.
  24. Liu K, et al. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J Clin Invest, 2009; 119(4): doi:10.1172/JCI36728
  25. Harley JB, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008; 40(2): 204-10
  26. Hutcheson J, et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity. 2008;28(2):206-17
  27. Li, QZ, et al. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndormes. Clin Exp Immunol. 2007;147(1):60-70
  28. Li, QZ, et al. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest. 2005;115(12):3428-39